Hair loss affects millions of people worldwide, with androgenetic alopecia (AGA) affecting up to 50% of men and 40% of women by the age of 50 years. While individual treatments can deliver meaningful results, the latest research reveals that combining Platelet-Rich Plasma (PRP) therapy with other proven treatments may offer superior outcomes for those seeking to restore their hair.
At PRP in Raleigh, we believe in evidence-based approaches to hair restoration. Let’s explore how combining PRP with other treatments can help you achieve the best possible results.
Understanding PRP Therapy
Platelet rich plasma (PRP) was described as a small volume of plasma containing higher concentrations of platelets than those found in peripheral blood. It was discovered that there are several growth factors and cytokines that can accelerate wound healing and tissue regeneration, leading to a wider range of applications in the medical field.
Activated platelets in PRP release numerous growth factors and cytokines from their alpha granules, including platelet-derived endothelial growth factor (PDGF), transforming growth factor β (TGF-β), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF), which play a major role in stimulating hair growth through cell proliferation, differentiation and angiogenesis.
The Power of Combination: PRP Plus Minoxidil
Research strongly supports the synergistic benefits of combining PRP with minoxidil. Patients who received complex therapy (applications of 5% minoxidil solution and PRP injections) obtained significant results: hair density increased by 32%, the average diameter of hair rods increased by 26%, and the intensity of hair loss decreased by 39%.
The results of using complex therapy significantly exceeded the clinical effect of platelet-rich plasma and topical applications of a 5% solution of minoxidil alone. The data obtained suggests that PRP and minoxidil potentiate each other’s action when used together and their complex application seems promising for the treatment of androgenetic alopecia.
A comprehensive meta-analysis confirmed these findings: A systematic review of the studies showed that all trials reported better outcomes with PRP plus Minoxidil than with Minoxidil alone. Additionally, significant improvement in hair density was noted in the PRP plus Minoxidil group compared to the Minoxidil group at all follow-up periods. Patient satisfaction was also significantly higher in the combined group than in Minoxidil alone.
FDA-Approved Treatments: Building Your Foundation
Currently, there are only two US Food and Drug Administration (FDA)-approved drugs for AGA: topical minoxidil and oral finasteride. Understanding how these work alongside PRP is essential for optimal results.
Minoxidil: Through an unclear mechanism, minoxidil enhances hair growth by enlarging miniaturized hair follicles, extending anagen, and shortening telogen. Minoxidil is FDA-approved for treating both male and female pattern hair loss.
Finasteride: Finasteride, a competitive inhibitor of type II 5-alpha reductase, decreases production of dihydrotestosterone. Finasteride is FDA-approved for treating male pattern hair loss, but not female pattern hair loss.
For more information on FDA-approved hair loss treatments, visit the U.S. Food and Drug Administration (FDA) official website.
PRP Plus Finasteride: Another Powerful Combination
Research has also examined the benefits of combining PRP with finasteride. A study performed on 80 patients with androgenetic alopecia found that the first group was treated with 6 PRP sessions spaced 1 month apart and 1 mg daily of oral finasteride, while the second group received finasteride and topical minoxidil. After 6 months, the PRP and Finasteride group showed a 16.8% improvement in hair density compared to the Minoxidil and Finasteride group.
Enhancing Hair Transplant Results with PRP
For patients undergoing hair transplant surgery, PRP can significantly enhance outcomes. PRP injections can be effective in treating male pattern baldness, both in preventing hair loss and promoting new hair growth. PRP can also aid in the stimulation of hair growth after hair transplants.
The quality of hair was better in the PRP-treated group compared to the non-PRP group. In the PRP group, multiple erupting roots from the graft as early as 3 months besides lengthier shafts clearly suggest the role of growth factors in stimulating as well as nourishing transplanted follicular unit grafts.
After receiving 3 PRP treatments a month for 3 months starting a week after their hair transplant, a significant increase in hair shaft length and follicular density was observed at the 1, 2, 3 and 6-month checkups, compared to placebo.
For comprehensive information about hair loss research and studies, visit the National Institutes of Health (NIH) and PubMed Central.
What the Research Concludes
There was a general consensus on the positive effects of PRP, although results varied due to differences in preparation protocols, platelet concentration, and delivery methods. Additionally, combining PRP with other treatments, such as microneedling or topical medications like minoxidil, showed enhanced efficacy in several studies.
PRP treatment was more effective than minoxidil therapy. Complex therapy turned out to be more effective than minoxidil monotherapy and PRP monotherapy.
Creating Your Personalized Treatment Plan
The variability in treatment protocols highlights the need for standardized PRP preparation and application methods. Future research should focus on refining these protocols and exploring the potential of combination therapies to maximize treatment effectiveness and consistency.
At PRP in Raleigh, we work with each patient to develop a customized treatment approach based on their unique hair loss pattern, goals, and medical history. Our combination protocols may include:
- PRP therapy as a foundation treatment
- Topical minoxidil to enhance blood flow and follicular activity
- Oral finasteride (for appropriate male candidates) to block DHT
- Low-level laser therapy for added stimulation
- Nutritional support for overall hair health
Take the Next Step
Studies have revealed encouraging results for the treatment of male and female pattern hair loss with PRP. The autologous treatment was rated with high satisfaction scores and can be considered a safe and effective treatment modality.
If you’re ready to explore how combining PRP with other treatments can maximize your hair restoration results, contact PRP in Raleigh today to schedule your consultation. Our experienced team will help you understand your options and create a personalized treatment plan designed to help you achieve fuller, healthier hair.